He served on the Board of ICICI Ltd/ICICI Bank from 1997 to 2003. During this period, the market cap of the Bank increased fifty-three times. He served on the Board of ICICI Ltd/ICICI Bank from 1997 to 2003. He served on the Board of Infosys Ltd from 2011 to 2017 and was the Chairman from June 2015 to August 2017. Presently, he serves on the Board of Asian Paints Ltd. Seshasayee was the President of Confederation of Indian Industry (CII) during 2006-07 and has been an active leader of CII for over 25 years. He was the President of Society of Indian Automobile Manufacturers (SIAM), the apex body representing the Indian automobile industry during 2001-03.
Seshasayee has served on several government and professional committees. As a member of Government of India delegations, Seshasayee was an active participant at the Doha Ministerial Round of WTO in 2001 and the Hong Kong Ministerial at Hong Kong in 2005. Seshasayee was also the Co-Chair of the World Economic Forum Middle East during 2007. He has served as the Chairman of the Board of Governors of the National Institute of Technology, Tiruchirapalli (NIIT) and as the Chairman of the Indian Institute of Information Technology Design and Manufacturing (IITD & M), Kancheepuram.
He is presently the Chairman of the Executive committee of Krea University. Seshasayee is the Chairman of the Executive Council of the Cancer Institute, Chennai; Chairman of Schizophrenia Research Foundation (SCARF) and Vice President of the Music Academy, Chennai. Seshasayee has won many honours and recognition, including the ‘Star of Italian Solidarity’ award by the Italian Government, Sir Jehangir Ghandy Medal for Industrial and Social Peace by XLRI, Jamshedpur, and the ‘Lifetime Achievement Award’ by the Institute of Chartered Accountants of India.